Glucocorticoids - steroids synthesized by the adrenal cortex. Natural steroids and their synthetic analogues are used in medicine for adrenal insufficiency. In addition, for some diseases used inflammatory, immunosuppressive, anti-allergic, anti-shock and other properties of these preparations.
In addition, glucocorticoids improve microcirculation in the inflammation, causing vasoconstriction of the capillaries, reduces fluid exudation. Glucocorticoids stabilize cell membranes, including lysosomal membranes, preventing the output of lysosomal enzymes and thereby reducing their concentration at the site of inflammation. Prednisone protivoalergichesky anti-inflammatory drug and a broad spectrum of action. It stabilizes cell membranes, reduces the yield of proteolytic enzymes from lysosomes, inhibits the A2 phospholipase, violates liberatiou arachidonic acid, inhibits the activity of hyaluronidase and reduces the permeability of capillaries, fibroblast activity.
Buy Prednisone online, affects the alterative and exudative phase of inflammation, prevents the spread of the inflammatory process. This drug inhibits the formation of mucopolysaccharides, limiting water and plasma protein binding in the outbreak of rheumatic inflammation. It inhibits collagenase activity, preventing the destruction of cartilage and bone in rheumatoid arthritis.
Prednisone is due to the wide spectrum of action prescribed for such diseases:
eczema, pruritus, exfoliative dermatitis, psoriasis, pruritus, seborrheic dermatitis, lupus erythematosus, erythroderma, alopecia;
Rheumatism, rheumatoid arthritis, dermatomyositis, periarteritis nodosa, scleroderma, ankylosing spondylitis;
various forms of leukemia, Hodgkin's disease, thrombocytopenic purpura, hemolytic anemia, infectious mononucleosis;
acute adrenal insufficiency;
congenital adrenal hyperplasia;
hepatitis, hepatic coma, hypoglycemic state, lipoid nephrosis, agranulocytosis;
prevention and treatment of shock.
The price of the drug depends on the country of origin, but you have the opportunity to buy the drug prednisone at an affordable price in the online pharmacy without overpaying. The main principle of glucocorticoid therapy - to achieve maximum therapeutic effect with minimal doses. The dosage regimen is selected strictly individually, mostly depending on the nature of the disease, the patient's condition and response to treatment than the age or body weight.
The drug prednisone is necessary to cancel the gradual reduction of the dose and the consumption of the drug due to the presence of the syndrome. Due to the side effects of prednisone is used only when there are clear indications and under close medical supervision. Prednisone is a synthetic glucocorticoid average duration - period poluvyvedniya 18-36 hours.
A characteristic feature of glucocorticoid drugs is an immunosuppressive activity. Immunosuppressive properties prednisone mitostaticheskim not associated with the action, and are the result of suppression of different stages of the immune response: Migration inhibition of bone marrow stem cells and B cells, and the suppression activity of T B-lymphocytes and inhibition of cytokine release from leukocytes and macrophages.
It is noteworthy that glucocorticoids immunosuppressive effect allows their use in the transplantation of organs and tissues for suppressing rejection reactions, as well as in various autoimmune diseases.
Antitoxic and prednisone antishock effect due to an increase in blood pressure, activation of liver enzymes involved in the metabolism of endo- and xenobiotics. Prednisone has a marked impact on all types of metabolism: protein, carbohydrate, mineral and fat. Effect on protein metabolism is expressed as inhibition of synthesis of protein catabolism and acceleration, particularly in the skin, muscle and bone tissue. From the carbohydrate metabolism is manifested by the fact that they stimulate gluconeogenesis in the liver, increases blood glucose (available glucosuria), contribute to the accumulation of glycogen in the liver. From the carbohydrate metabolism in the liver stimulates gluconeogenesis, increased blood glucose levels, the accumulation of glycogen in the liver. The accumulation of glycogen in the liver is manifested by muscle weakness, atrophy of the skin and muscles, delayed wound healing.
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Prednisone is virtually trapped in the body of sodium and water by increasing the reabsorption in the renal tubules, not stimulates the excretion of potassium. At the use of any drug group glucocorticoids need to consume more food kaltsiesoderzhaschih products. After prednisone marked changes in the blood: reducing the number of lymphocytes, monocytes, eosinophils, basophils in peripheral blood with simultaneous development of neutrophil leukocytosis, increased erythrocyte content.